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Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
---|---|---|---|---|---|
Phospho-YAP (Ser127) (D9W2I) Rabbit mAb 13008 | 20 µl |
|
H M R | 65-78 | Rabbit IgG |
Phospho-YAP (Ser397) (D1E7Y) Rabbit mAb 13619 | 20 µl |
|
H M R | 65-78 | Rabbit IgG |
Phospho-TAZ (Ser89) (E1X9C) Rabbit mAb 59971 | 20 µl |
|
H M R | 55 | Rabbit IgG |
YAP/TAZ (D24E4) Rabbit mAb 8418 | 20 µl |
|
H M Mk | 55, 78 | Rabbit IgG |
YAP (D8H1X) XP® Rabbit mAb 14074 | 20 µl |
|
H M R Hm Mk | 65-78 | Rabbit IgG |
TAZ (D3I6D) Rabbit mAb 70148 | 20 µl |
|
H M | 50 | Rabbit IgG |
Phospho-YAP (Ser109) (E5I9G) Rabbit mAb 53749 | 20 µl |
|
H M R Mk | 65-78 | Rabbit IgG |
Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Goat |
Product Information
Monoclonal antibodies are produced by immunizing rabbits with recombinant protein corresponding to the carboxy terminus of human YAP protein and synthetic peptides corresponding to Ala200 of mouse TAZ protein and Asp362 of human TAZ protein. Phosphorylation-specific antibodies are produced by immunizing rabbits with synthetic phospho-peptides corresponding to Ser109, Ser127, and Ser397 of human YAP protein, and Ser89 of human TAZ protein.
YAP and TAZ (WWTR1) are transcriptional co-activators that play a central role in the Hippo Signaling pathway that regulates cell, tissue and organ growth. YAP and TAZ are structurally and functionally similar, but exhibit differential patterns of expression among cells and tissues that suggest partially non-redundant functions (1). YAP and TAZ are dynamically regulated in response to internal and external cellular signals. Under growth conditions, YAP and TAZ are translocated to the nucleus, where they interact with transcription factors (e.g., TEA domain proteins) that regulate the transcription of genes that control proliferation and cell survival (2). The subcellular localization of YAP and TAZ is dynamically regulated by a kinase cascade that regulates the phosphorylation status of key residues within YAP and TAZ. Phosphorylation of YAP and TAZ (e.g., Ser109, Ser127, Ser397 in YAP; Ser89 in TAZ) results in their cytoplasmic translocation, sequestration by 14-3-3 proteins, and recruitment of the β-TrCP (SCF) ubiquitin ligase complex (3,4). This complex ubiquitinates YAP and TAZ, triggering their proteolytic degradation in the proteasome, thereby altering the transcription of genes that control proliferation and cell survival (3-5).
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